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    <ns5:termsAndConditions xml:lang="en">Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.</ns5:termsAndConditions>
    <ns0:brs_strainTypeLink rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/StrainType_17"/>
    <dc:description xml:lang="ja">Rapgef4 (Epac2)は低分子量Gタンパク質RapのGEFであり、膵β細胞においてはPKAとともにcAMPシグナルによるグルコース応答性インスリン分泌反応の増幅系に関与する。適切なプロモーターによるCreリコンビナーゼの発現によって、組織特異的遺伝子欠損が期待される。</dc:description>
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    <ns5:addinfo>Necessary documents for ordering:&lt;ol&gt;&lt;li&gt;Approval form (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_6.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_d.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;li&gt;Order form (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;li&gt;Category I MTA: MTA for distribution with RIKEN BRC (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;li&gt;Acceptance of responsibility for living modified organism (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_7.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_g.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;/ol&gt;</ns5:addinfo>
    <dcterms:identifier>RBRC09391</dcterms:identifier>
    <ns5:application>Cre/loxP system</ns5:application>
    <rdfs:label>B6;129-Rapgef4&lt;tm1Sse&gt;</rdfs:label>
    <rdfs:label xml:lang="en">B6;129-Rapgef4&lt;tm1Sse&gt;</rdfs:label>
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    <ns1:ESCellLine>R1 [(129X1/SvJ x 129S1/Sv)F1-Kitl&lt;+&gt;]</ns1:ESCellLine>
    <ns1:expectedDelivery xml:lang="ja">C（3〜6か月）</ns1:expectedDelivery>
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    <ns1:strainDevelopment xml:lang="ja">神戸大学・清野進先生R1 ES細胞を用いて相同組み換え体を作製し作製。その後C57Bl6/Jに５代以上戻し交配。</ns1:strainDevelopment>
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    <ns0:brs_hasAllele rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/brc_allele2682"/>
    <skos:altLabel xml:lang="ja">Epac2-flox</skos:altLabel>
    <skos:altLabel xml:lang="en">Epac2-flox</skos:altLabel>
    <ns1:strainDevelopment xml:lang="ja">神戸大学・清野進先生 R1 ES細胞を用いて相同組み換え体を作製し作製。その後C57Bl6/Jに５代以上戻し交配。</ns1:strainDevelopment>
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    <ns1:expectedDelivery xml:lang="en">C (3-6 months)</ns1:expectedDelivery>
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    <ns0:brs_depositor xml:lang="en">Seino, Susumu</ns0:brs_depositor>
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    >true</ns1:isRecombinant>
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    <ns0:brs_depositor xml:lang="ja">清野　進</ns0:brs_depositor>
    <ns1:donorDNA>Phage P1 loxP sites, herpes simplex virus thymidine kinase promoter (HSV tk promoter), E. coli neo, mouse Rapgef4 genomic DNA</ns1:donorDNA>
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    <ns10:citesAsAuthority rdf:resource="http://rdf.ncbi.nlm.nih.gov/pubmed/18040047"/>
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    <ns5:termsAndConditions xml:lang="ja">条件を付加する。利用者は提供承諾書を用いて、事前に寄託者の承諾を得る。</ns5:termsAndConditions>
    <ns5:addinfo>&lt;a href='https://brc.riken.jp/mus/pcr09391'&gt;Genotyping protocol -PCR-&lt;/a&gt;</ns5:addinfo>
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    <rdfs:seeAlso rdf:resource="http://www2.brc.riken.jp/lab/animal/detail.php?brc_no=RBRC09391"/>
    <dcterms:references rdf:resource="http://identifiers.org/pubmed/18040047"/>
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    <ns0:brs_hasGenomicFeature rdf:parseType="Resource">
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    <ns5:application>Endocrine Deficiency Research</ns5:application>
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    <ns0:brs_hasGenomicFeature rdf:parseType="Resource">
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  <rdf:Description rdf:about="http://metadb.riken.jp/db/rikenbrc_mouse/HealthCertificate_146290">
    <ns0:brs_indicatesStrain rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/RBRC09391"/>
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  <rdf:Description rdf:about="http://metadb.riken.jp/db/rikenbrc_mouse/HealthCertificate_146289">
    <ns0:brs_indicatesStrain rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/RBRC09391"/>
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  <rdf:Description rdf:about="http://metadb.riken.jp/db/rikenbrc_mouse/HealthCertificate_146288">
    <ns0:brs_indicatesStrain rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/RBRC09391"/>
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  <rdf:Description rdf:about="http://metadb.riken.jp/db/rikenbrc_mouse/HealthCertificate_146287">
    <ns0:brs_indicatesStrain rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/RBRC09391"/>
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  <rdf:Description rdf:about="http://metadb.riken.jp/db/rikenbrc_mouse/HealthCertificate_146286">
    <ns0:brs_indicatesStrain rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/RBRC09391"/>
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